Flow Cytometry Identifies Changes in Peripheral and Intrathecal Lymphocyte Patterns in CNS Autoimmune Disorders and Primary CNS Malignancies

Flow Cytometry Identifies Changes in Peripheral and Intrathecal Lymphocyte Patterns in CNS Autoimmune Disorders and Primary CNS Malignancies

Medicine, Rheumatology and Immunology, Medical Laboratory Science, Neurology, Medical Imaging, Oncology, Life Sciences, Immunology,
flow cytometry   central nervous system   autoimmune disorders   malignancies   lymphocytes   immunophenotyping   early diagnosis  

New Insights into CNS Disease Immunology Mechanisms Revealed by Multidimensional Flow Cytometry In immunological research, understanding the immunopathological mechanisms of central nervous system (CNS) diseases is crucial for early diagnosis and treatment decisions. A study published in Journal of Neuroinflammation in 2024 used multidimensional fl...

Activating Point Mutations in the MET Kinase Domain Represent a Unique Molecular Subset of Lung Cancer and Other Malignancies Targetable with MET Inhibitors

Medicine, Respiratory System, Oncology, Life Sciences, Biochemistry, Genetics,
MET   kinase domain   point mutation   lung cancer   malignancies   targeted therapy  

This study reveals a new targetable cancer subtype characterized by activating point mutations in the MET tyrosine kinase domain (TKD). Researchers identified MET TKD activating mutations in approximately 0.5% of patients across a genomic data set of over 600,000 cancer cases, encompassing various tumor types, with the highest prevalence in renal c...