Complete Human Recombination Maps

Medicine, Life Sciences, Genetics,
recombination maps   non-cross-over recombination   sex-specific   mutations   meiosis  

Complete Human Recombination Maps Academic Background In genetic research, recombination is one of the key mechanisms by which organisms generate genetic diversity. Recombination not only affects the transmission and combination of genes but also plays a crucial role in natural selection and population history inference. However, existing recombina...

Genomic Profiling of Small Bowel Adenocarcinoma: A Pooled Analysis from 3 Databases

Medicine, Medical Laboratory Science, Gastroenterology, Oncology, Life Sciences, Biochemistry, Genetics,
small bowel adenocarcinoma   genomic profiling   mutations   prognosis   staging   prognostic factors   biomarkers  

Overview of Genomics in Small Bowel Adenocarcinoma: A Data Integration Analysis Based on Three Major Databases Background and Significance of the Study Small Bowel Adenocarcinoma (SBA) is a rare tumor, but its incidence has increased in recent years, especially in duodenal adenocarcinoma. Approximately 20% of SBA patients have certain susceptibilit...

Mechanisms of Response and Tolerance to Active RAS Inhibition in KRAS-Mutant NSCLC

Medicine, Basic Medical Sciences, Oncology, Life Sciences, Cell Biology, Biochemistry,
KRAS   mutations   NSCLC   active RAS inhibition   drug-tolerant persisters  

Response and Resistance Mechanisms of RAS Inhibitors in KRAS-Mutant NSCLC Research Background With the clinical development of RAS inhibitors, the treatment of KRAS-mutant Non-Small Cell Lung Cancer (NSCLC) faces a new turning point. However, in clinical practice, patients show poor long-term responses to RAS inhibitors, influencing clinical effica...