Integrative Analysis of Ewing’s Sarcoma Reveals the MIF-CD74 Axis as a Target for Immunotherapy

Medicine, Oncology, Life Sciences, Immunology,
Ewing’s sarcoma   immunotherapy   MIF-CD74 axis   tumor microenvironment   single-cell RNA sequencing  

Discovery of a New Immunotherapy Target for Ewing Sarcoma Background Introduction Ewing sarcoma (Ewing’s sarcoma, EWS) is a common pediatric bone cancer, accounting for approximately 2% of childhood cancers. Despite significant advances in immune checkpoint inhibitors (ICIs) and CAR-T cell therapy in various cancers, their efficacy in Ewing sarcoma...

Meningeal Solitary Fibrous Tumor Cell States Phenocopy Cerebral Vascular Development and Homeostasis

Medicine, Neurology, Neurosurgery, Oncology,
meningeal solitary fibrous tumor   single-cell RNA sequencing   spatial transcriptomics   cell-cell interactions   cerebral vascular development   tumor microenvironment   WHO histological grading  

Single-Cell and Spatial Transcriptomics Study of Meningeal Solitary Fibrous Tumors Academic Background Meningeal Solitary Fibrous Tumors (SFTs) are rare mesenchymal tumors originating from the meninges of the central nervous system (CNS). Although SFTs are histologically similar to other meningeal tumors (such as meningiomas), their unique clinical...

BRD4 Inhibitor Reduces Exhaustion and Blocks Terminal Differentiation in CAR-T Cells by Modulating BATF and EGR1

Medicine, Hematology, Oncology, Life Sciences, Cell Biology, Biochemistry, Immunology,
CAR-T cell exhaustion   BRD4 inhibitor   single-cell RNA sequencing   transcriptional factors   acute myeloid leukemia  

Acute myeloid leukemia (AML) is the most common type of leukemia in adults. Although most AML patients achieve complete remission after standard chemotherapy, refractory and relapsed disease remain a significant challenge. Over the past decade, immunotherapy has been widely applied in cancer treatment, particularly chimeric antigen receptor T-cell ...

Cycling Alpha Cells in Regenerative Drug-Treated Human Pancreatic Islets May Serve as Key Beta Cell Progenitors

Medicine, Endocrinology, Life Sciences, Cell Biology,
regenerative drugs   alpha cells   beta cells   pancreatic islets   diabetes   cell differentiation   single-cell RNA sequencing  

Academic Background Diabetes is a global health issue affecting over 500 million people. Both type 1 diabetes (T1D) and type 2 diabetes (T2D) share the common feature of a significant reduction in the number of functional insulin-secreting beta cells. Therefore, restoring or increasing beta cell mass is considered a key strategy in diabetes treatme...

Single-Cell RNA Sequencing and Machine Learning Reveal Relationship Between CD8+ T Cells and Uveal Melanoma Metastasis

Medicine, Oncology,
single-cell RNA sequencing   uveal melanoma   metastasis risk   immune microenvironment   CD8+ T cells   machine learning   tumor microenvironment  

Academic Report on “Machine Learning and Single-cell RNA Sequencing Reveal Relationship Between Intratumor CD8+ T Cells and Uveal Melanoma Metastasis” published in Cancer Cell International in 2024 Research Background and Purpose Uveal melanoma (UM) is the most common intraocular malignant tumor in adults. After receiving radiation or surgical trea...

Regulation of XIST Gene Silencing in Embryonic Development: Analysis of Human and Bovine Preimplantation Embryos

Life Sciences, Genetics,
X chromosome silencing   XIST gene   preimplantation embryos   embryonic development   gene regulation   bovine   single-cell RNA sequencing  

Exploring XIST Silencing and Repressor Factors on the X Chromosome in Early Human and Bovine Embryos Research Background X chromosome inactivation is a dosage compensation mechanism in mammals, aimed at balancing the expression of X-linked genes between females and males. The XIST gene locus can trigger transcriptional silencing of the additional X...

Spatiotemporal Transcriptomic Changes of Human Ovarian Aging and the Regulatory Role of FOXP1

Medicine, Obstetrics and Gynecology, Geriatrics, Life Sciences, Biochemistry, Genetics,
ovarian aging   single-cell RNA sequencing   spatial transcriptomics   FOXP1   gene expression   DNA damage   cell types  

Research Report on Spatiotemporal Transcriptomic Changes in Human Ovarian Aging and the Regulatory Role of FOXP1 Academic Background With the continuous increase in global average life expectancy, health issues faced by women during menopause are receiving increasing attention. Ovarian aging is one of the significant issues, closely related to vari...