Single-Cell RNA Sequencing and Machine Learning Reveal Relationship Between CD8+ T Cells and Uveal Melanoma Metastasis

Medicine, Oncology,
single-cell RNA sequencing   uveal melanoma   metastasis risk   immune microenvironment   CD8+ T cells   machine learning   tumor microenvironment  

Academic Report on “Machine Learning and Single-cell RNA Sequencing Reveal Relationship Between Intratumor CD8+ T Cells and Uveal Melanoma Metastasis” published in Cancer Cell International in 2024 Research Background and Purpose Uveal melanoma (UM) is the most common intraocular malignant tumor in adults. After receiving radiation or surgical trea...

Regulation of XIST Gene Silencing in Embryonic Development: Analysis of Human and Bovine Preimplantation Embryos

Life Sciences, Genetics,
X chromosome silencing   XIST gene   preimplantation embryos   embryonic development   gene regulation   bovine   single-cell RNA sequencing  

Exploring XIST Silencing and Repressor Factors on the X Chromosome in Early Human and Bovine Embryos Research Background X chromosome inactivation is a dosage compensation mechanism in mammals, aimed at balancing the expression of X-linked genes between females and males. The XIST gene locus can trigger transcriptional silencing of the additional X...

Spatiotemporal Transcriptomic Changes of Human Ovarian Aging and the Regulatory Role of FOXP1

Medicine, Obstetrics and Gynecology, Geriatrics, Life Sciences, Biochemistry, Genetics,
ovarian aging   single-cell RNA sequencing   spatial transcriptomics   FOXP1   gene expression   DNA damage   cell types  

Research Report on Spatiotemporal Transcriptomic Changes in Human Ovarian Aging and the Regulatory Role of FOXP1 Academic Background With the continuous increase in global average life expectancy, health issues faced by women during menopause are receiving increasing attention. Ovarian aging is one of the significant issues, closely related to vari...