Multiscale Footprints Reveal the Organization of Cis-Regulatory Elements

Information Science, Artificial Intelligence, Life Sciences, Cell Biology, Biochemistry, Bioengineering, Genetics,
cis-regulatory elements   chromatin accessibility   transcription factors   deep learning   single-cell sequencing   genomics   cell differentiation  

Multiscale Footprints Reveal the Role of Cis-Regulatory Elements in Cell Differentiation and Aging Background Introduction The regulation of gene expression is a key mechanism in cell fate determination and disease development, and cis-regulatory elements (CREs) play a crucial role in this process. CREs dynamically regulate gene expression by bindi...

JAK2/mTOR Inhibition Fails to Prevent Acute GVHD Despite Reduced Th1/Th17 Cells: Final Phase 2 Trial Results

Medicine, Hematology, Life Sciences, Immunology,
JAK2/mTOR inhibition   acute GVHD   Th1/Th17 cells   allogeneic hematopoietic cell transplantation   clinical trial   immunosuppression   cell differentiation  

Inhibition of JAK2/mTOR Fails to Effectively Prevent Acute Graft-versus-Host Disease (GVHD): Limitations of Targeting Th1/Th17 Cells In recent years, the role of systemic immunosuppressive therapies in preventing acute graft-versus-host disease (aGVHD) following allogeneic hematopoietic cell transplantation (alloHCT) has come under scrutiny. Th1 (T...

Cycling Alpha Cells in Regenerative Drug-Treated Human Pancreatic Islets May Serve as Key Beta Cell Progenitors

Medicine, Endocrinology, Life Sciences, Cell Biology,
regenerative drugs   alpha cells   beta cells   pancreatic islets   diabetes   cell differentiation   single-cell RNA sequencing  

Academic Background Diabetes is a global health issue affecting over 500 million people. Both type 1 diabetes (T1D) and type 2 diabetes (T2D) share the common feature of a significant reduction in the number of functional insulin-secreting beta cells. Therefore, restoring or increasing beta cell mass is considered a key strategy in diabetes treatme...