TRIM21-Mediated Ubiquitination and Phosphorylation of ERK1/2 Promotes Cell Proliferation and Drug Resistance in Pituitary Adenomas

Medicine, Endocrinology, Neurology, Neurosurgery, Oncology,
TRIM21   ERK1/2   pituitary adenomas   cell proliferation   drug resistance   ubiquitination   phosphorylation  

Academic Background Pituitary adenomas (PAs) are common intracranial tumors with complex pathogenesis, often accompanied by abnormal hormone secretion. Although various treatments, such as dopamine agonists (DAs), are currently available, some patients exhibit drug resistance, leading to suboptimal therapeutic outcomes. Therefore, identifying new t...

Metformin Blocks BIK1-Mediated CPK28 Phosphorylation and Enhances Plant Immunity

Life Sciences, Biochemistry, Immunology, Botany,
metformin   plant immunity   CPK28   phosphorylation   plant immunity inducer  

Metformin Enhances Plant Immunity by Blocking BIK1-Mediated CPK28 Phosphorylation Academic Background In the context of the increasingly severe global food security issues, controlling crop diseases has become a major challenge in agricultural production. Although traditional chemical pesticides can effectively control diseases, the environmental p...

Phosphorylation of BOK at Ser-8 Blocks Its Ability to Suppress IP3R-Mediated Calcium Mobilization

Medicine, Life Sciences, Cell Biology, Biochemistry,
BOK   phosphorylation   IP3R   calcium mobilization   endoplasmic reticulum   GPCR   calcium signaling  

The New Role of BOK Protein in Calcium Signaling Regulation Background Introduction BOK (Bcl-2-related ovarian killer) is a member of the Bcl-2 protein family and has long been thought to play a role in cell apoptosis. However, recent studies suggest that BOK may also have non-apoptotic functions, particularly in the regulation of calcium ion (Ca²⁺...