Research Report on Changes in the Metabolome of Senescent Myoblasts Research Background As age increases, the function of skeletal muscle gradually deteriorates, a phenomenon closely related to the senescence of muscle stem cells (satellite cells). Satellite cells play a key role in muscle injury repair. However, during the aging process, the funct...

Exploring the Impacts of Senescence on Implantation and Early Embryonic Development Using Totipotent Cell-Derived Blastoids Academic Background With the increasing trend of delayed childbearing in modern society, reproductive issues among women of advanced maternal age (AMA) have become increasingly prominent. Studies have shown that the implantati...

Alzheimer’s disease (AD) is an age-related chronic neurodegenerative disorder, whose pathological mechanism involves multiple factors, including brain inflammation. Microglia, particularly those expressing the AD risk gene TREM2, are believed to play a crucial role in the development of AD, but their exact contribution has not been fully elucidated...