Mitochondrial Serine Catabolism Maintains Hematopoietic Stem Cell Pool in Homeostasis and Injury

Research Background The maintenance and repair of the hematopoietic system are crucial for the continuation of life and health in an organism. As the foundation of the hematopoietic system, the stability of hematopoietic stem cells (HSCs) is particularly important. The maintenance of the HSC pool relies on intrinsic and extrinsic factors, among whi...

Dietary Intake and Glutamine-Serine Metabolism Control Pathologic Vascular Stiffness

Research Background Cardiovascular diseases (CVDs) are one of the leading causes of death worldwide, with vascular remodeling and stiffness being critical indicators that significantly affect disease progression and prognosis. Recent studies have increasingly focused on the role of vascular fibroblasts in vascular stiffness and remodeling. In parti...