Synergistic Combination of Perphenazine and Temozolomide Suppresses Patient-Derived Glioblastoma Tumorspheres

Medicine, Neurology, Oncology,
glioblastoma   perphenazine   temozolomide   tumorspheres   combination therapy   apoptosis   stemness  

Academic Background Glioblastoma (GBM) is a highly malignant primary brain tumor. Despite current standard treatments such as surgical resection, radiotherapy, and chemotherapy, the prognosis remains extremely poor, with a median survival of only 14.6 months. Traditional treatments often fail to completely eradicate the tumor and are prone to recur...

Inhibitory Fcγ Receptor Deletion Enhances CD8 T Cell Stemness Increasing Anti-PD-1 Therapy Responsiveness Against Glioblastoma

Medicine, Neurology, Oncology, Life Sciences, Cell Biology, Biochemistry, Immunology,
CD8 T cells   stemness   anti-PD-1 therapy   glioblastoma   tumor microenvironment  

Inhibitory Fcγ Receptor Deletion Enhances CD8 T Cell Stemness, Increasing Anti-PD-1 Therapy Responsiveness in Glioblastoma Background and Objectives of the Study Glioblastoma (GBM) is an aggressive central nervous system tumor with poor prognosis, and the median survival of patients is only 14.6 months. Despite the significant efficacy of immune ch...