Academic Research Report: MCL1 Copy Number Gain as a Therapeutic Target for Osteosarcoma Academic Background Osteosarcoma (OS) is a primary malignant bone tumor that predominantly affects children and adolescents. Although the treatment regimen combining surgery with chemotherapy was established in the 1970s and remains the standard therapy, progre...

Therapeutic Potential of Synergistic Targeted Inhibition of HSP90AB1 and PARP1 in Prostate Cancer Cells: A Review of Celastrol and Olaparib Combination Therapy Background Prostate Cancer (PCA) is one of the most common malignancies among men worldwide, with its incidence continually rising in recent years, making early screening and treatment cruci...

Analysis of Intratumor Heterogeneity in Liver Cancer Using Pharmacogenomics: A Study Based on a Large-Scale Organoid Biobank Academic Background Primary liver cancer (PLC) is the third leading cause of cancer-related deaths worldwide, mainly comprising hepatocellular carcinoma (HCC), intrahepatic cholangiocarcinoma (ICC), and a mixed form called co...