ROR1 Facilitates Glioblastoma Growth via Stabilizing GRB2 to Promote c-fos Expression in Glioma Stem Cells

Medicine, Neurology, Oncology,
glioblastoma   glioma stem cells   ROR1   GRB2   c-fos   tumor growth   signaling pathway  

Academic Background Glioblastoma (GBM) is the most common and aggressive primary brain tumor, with significant treatment challenges and a poor prognosis. Despite advancements in surgery, chemotherapy, and radiotherapy, the 5-year survival rate for GBM patients remains below 4%. The recurrence and therapeutic resistance of GBM are primarily attribut...

Development of an Orthotopic Medulloblastoma Zebrafish Model for Rapid Drug Testing

Medicine, Pediatrics, Neurology, Oncology,
medulloblastoma   zebrafish model   drug testing   neural stem cells   tumor growth  

Academic Background Medulloblastoma (MB) is one of the most common malignant brain tumors in children. Although recent advances in molecular characterization and multimodal treatment have significantly improved patient survival rates, the prognosis of medulloblastoma remains closely related to molecular subtypes, particularly for patients with Grou...

Modeling of Glioma Growth with Mass Effect by Longitudinal Magnetic Resonance Imaging

Mathematics, Medicine, Medical Laboratory Science, Medical Imaging, Oncology, Life Sciences, Cell Biology, Bioengineering,
glioma   mass effect   tumor growth   magnetic resonance imaging   mathematical model  

Study of Mathematical Models for Tumor Growth – Exploring Glioma Extension Using Longitudinal Magnetic Resonance Imaging A recent article published in the IEEE Transactions on Biomedical Engineering presents a systematic study on the mathematical modeling and growth patterns of gliomas (glioma). This research was conducted by Birkan Tunç, David A. ...