Modulation of Viability, Proliferation, and Stemness by Rosmarinic Acid in Medulloblastoma Cells: Involvement of HDACs and EGFR

Medicine, Pediatrics, Basic Medical Sciences, Oncology, Life Sciences, Biochemistry,
rosmarinic acid   epidermal growth factor receptor   histone deacetylase inhibitor   stem cell-like phenotype   medulloblastoma   brain tumor  

Pediatric medulloblastoma (MB) is the most common malignant pediatric brain tumor. Due to its unique molecular and clinical characteristics, the treatment of this type of tumor has been a focus of clinical research. Existing treatments mainly include maximal surgical resection, radiotherapy, and chemotherapy, but these treatments often lead to long...

Clinically Unfavorable Transcriptome Subtypes of Non-WNT/Non-SHH Medulloblastomas are Associated with a Predominance in Proliferating and Progenitor-Like Cell Subpopulations

Medicine, Pediatrics, Neurology, Oncology, Life Sciences, Cell Biology, Biochemistry,
medulloblastoma   non-WNT   non-SHH   subgroups   deconvolution   prognosis  

Association of Adverse Transcriptomic Subtypes of Non-WNT/Non-SHH Medulloblastoma with the Dominance of Proliferative and Progenitor-like Subpopulations Research Background Medulloblastoma (MB) is one of the most common malignant tumors of the central nervous system in children. Based on molecular characteristics, the medical community typically cl...

Treatment response as surrogate to predict risk for disease progression in pediatric medulloblastoma with persistent MRI lesions after first-line treatment

Medicine, Pediatrics, Neurosurgery, Medical Imaging, Oncology,
medulloblastoma   persistent lesions   treatment response   disease progression   prognosis prediction  

Response to First-Line Treatment of Persistent MRI Lesions in Pediatric Medulloblastoma as a Surrogate Marker for Predicting Risk of Disease Progression Medulloblastoma is one of the most common malignant central nervous system tumors in children. Although the multimodal treatment concept has significantly improved the prognosis for patients, the o...