Oncogenic KRAS-dependent Stromal Interleukin-33 Directs the Pancreatic Microenvironment to Promote Tumor Growth

The Role of IL-33 in Promoting Tumor Growth in Pancreatic Cancer Tissue and its Potential as a Therapeutic Target Background Introduction Pancreatic Cancer (PDA) is one of the most lethal malignancies worldwide, characterized by rapid clinical progression and poor treatment responses, with a five-year survival rate of only 13%. In the United States...

Patient-derived mini-colons enable long-term modeling of tumor–microenvironment complexity

Patient-derived mini-colons enable long-term modeling of tumor–microenvironment complexity

Long-term Model for Studying Tumor Microenvironment Complexity: Patient-derived Mini-colons Background: The interaction between tumors and their surrounding microenvironment has profound implications for cancer development and treatment. However, existing in vitro tumor models lack the ability to capture these complex interactions. To address this ...