Acetyl-CoA Carboxylase Obstructs CD8+ T Cell Lipid Utilization in the Tumor Microenvironment

Medicine, Rheumatology and Immunology, Oncology, Life Sciences, Cell Biology, Biochemistry, Immunology,
Acetyl-CoA Carboxylase   Tumor Microenvironment   CD8+ T Cells   Lipid Utilization   Lipid Droplets   Antitumor Immunity  

Inhibition of Acetyl-CoA Carboxylase Enhances Antitumor Immunity of Tumor-Infiltrating CD8+ T Cells Background and Objective In recent years, the impact of metabolic changes in the Tumor Microenvironment (TME) on the function of Tumor-Infiltrating Lymphocytes (TILs) has become a hot topic in immunological research. Although T cells possess strong a...

LRIG1 Engages Ligand VISTA and Impairs Tumor-Specific CD8+ T Cell Responses

Medicine, Basic Medical Sciences, Oncology, Life Sciences, Immunology,
LRIG1   VISTA   Tumor Immunotherapy   CD8+ T Cells   Immune Checkpoint Inhibition   Antitumor  

Interaction and Attenuation of Tumor-Specific CD8+ T Cell Responses by LRIG1 and VISTA Academic Background In recent years, the importance of immune checkpoint inhibitors (ICIs) such as Programmed Cell Death Protein 1 (PD-1) and Cytotoxic T-Lymphocyte Antigen 4 (CTLA-4) has received increasing attention. These inhibitors significantly improve the s...

Intratumoral Antigen Signaling Traps CD8+ T Cells to Confine Exhaustion to the Tumor Site

Intratumoral Antigen Signaling Traps CD8+ T Cells to Confine Exhaustion to the Tumor Site

Medicine, Rheumatology and Immunology, Basic Medical Sciences, Oncology, Life Sciences, Immunology,
Tumor Immunology   Antigen Signaling   CD8+ T Cells   Cell Exhaustion   Immunotherapy  

Research Progress in Cancer Immunology: Tumor-derived Antigen Signals Induce CD8+ T-cell Exhaustion Localized to the Tumor Site Research Background and Purpose In recent years, immunotherapy has shown great potential in cancer treatment. However, tracking the behavior of immune cells after receiving antigen signals remains a challenge. Within tumor...