Acetyl-CoA Carboxylase Obstructs CD8+ T Cell Lipid Utilization in the Tumor Microenvironment

Medicine, Rheumatology and Immunology, Oncology, Life Sciences, Cell Biology, Biochemistry, Immunology,
Acetyl-CoA Carboxylase   Tumor Microenvironment   CD8+ T Cells   Lipid Utilization   Lipid Droplets   Antitumor Immunity  

Inhibition of Acetyl-CoA Carboxylase Enhances Antitumor Immunity of Tumor-Infiltrating CD8+ T Cells Background and Objective In recent years, the impact of metabolic changes in the Tumor Microenvironment (TME) on the function of Tumor-Infiltrating Lymphocytes (TILs) has become a hot topic in immunological research. Although T cells possess strong a...

Neuronal AMPK Regulates Microglial Lipid Droplet Accumulation in Tauopathy Brain

Medicine, Neurology, Life Sciences, Cell Biology, Biochemistry, Bioengineering,
Neurons   AMPK   Lipid Droplets   Tauopathy   Microglia   Neuroinflammation   Lipid Metabolism  

Accumulation of Lipid Droplets in Microglia is Regulated by Neuronal AMPK Background and Research Question Alzheimer’s Disease (AD) is a common type of dementia characterized by neurofibrillary tangles and β-amyloid plaques. However, beyond these classical pathologies, changes in lipid metabolism are increasingly recognized as closely associated wi...