Unique Foxp3 Palmitoylation Regulates Tregs Function through Palmitoyltransferases Regulatory T cells (Tregs) play a crucial role in maintaining immune homeostasis and preventing excessive immune responses. As important suppressors of immune reactions, Tregs help maintain immune tolerance, thereby preventing autoimmune diseases. However, in the tum...

Research Report: Neutrophils Disrupt B-1a Cell Homeostasis by Targeting Siglec-G, Exacerbating Sepsis Background Sepsis is a life-threatening organ dysfunction caused by a dysregulated immune response to infection. The immune system dysfunction accompanying sepsis is primarily triggered by pathogen-associated molecular patterns (PAMPs) and damage-a...

Genome-wide screening identifies TRIM33 as an essential regulator of dendritic cell differentiation Background Dendritic cells (DCs) serve as a bridge between innate and adaptive immunity by recognizing pathogens through pattern recognition receptors (such as TLRs) and modulating antigen-specific T cell responses. DCs are mainly divided into two ty...