In Vivo Bruton's Tyrosine Kinase Inhibition Attenuates Alcohol-Associated Liver Disease by Regulating CD84-Mediated Granulopoiesis

Medicine, Infectious Diseases, Hepatobiliary System, Gastroenterology, Hematology, Life Sciences, Biochemistry, Immunology,
Bruton's Tyrosine Kinase   Alcohol-Associated Liver Disease   Granulopoiesis   Neutrophils   Liver Damage   Therapeutic Target  

Research Background Severe alcoholic hepatitis (ALD) is a fatal form of alcohol-associated liver disease (AALD). The course of ALD is usually accompanied by neutrophil infiltration in the liver, which significantly affects the severity of the condition. However, the specific effects of alcohol on neutrophil function remain unclear. Based on this, i...

Neutrophils Disrupt B-1a Cell Homeostasis by Targeting Siglec-G to Exacerbate Sepsis

Medicine, Infectious Diseases, Rheumatology and Immunology, Medical Laboratory Science, Life Sciences, Immunology,
Neutrophils   B-1a Cells   Siglec-G   Sepsis   Immune Regulation  

Research Report: Neutrophils Disrupt B-1a Cell Homeostasis by Targeting Siglec-G, Exacerbating Sepsis Background Sepsis is a life-threatening organ dysfunction caused by a dysregulated immune response to infection. The immune system dysfunction accompanying sepsis is primarily triggered by pathogen-associated molecular patterns (PAMPs) and damage-a...