Regulatory T Cells-Related Gene in Primary Sclerosing Cholangitis: Evidence from Mendelian Randomization and Transcriptome Data

Medicine, Hepatobiliary System, Medical Laboratory Science, Gastroenterology, Life Sciences, Immunology, Genetics,
Primary Sclerosing Cholangitis   Regulatory T Cells   Mendelian Randomization   Transcriptome Data   Machine Learning   Immune Cell Infiltration   Molecular Pathways  

Regulatory T Cells-Related Gene in Primary Sclerosing Cholangitis: Evidence from Mendelian Randomization and Transcriptome Data Authors: Jianlan Hu1, Youxing Wu1, Danxia Zhang1, Xiaoyang Wang1, Yaohui Sheng1, Hui Liao1, Yangpeng Ou2✉, Zhen Chen3, Baolian Shu1✉, and Ruohu Gui1✉ Journal: Genes & Immunity (2024) 25:492–513 DOI: https://doi.org/10.1038...

Distinct Palmitoylation of FoxP3 Regulates the Function of Regulatory T Cells via Palmitoyltransferases

Medicine, Rheumatology and Immunology, Oncology, Life Sciences, Cell Biology, Biochemistry, Immunology,
Regulatory T Cells   FoxP3   Palmitoylation   Palmitoyltransferases   Immune Regulation  

Unique Foxp3 Palmitoylation Regulates Tregs Function through Palmitoyltransferases Regulatory T cells (Tregs) play a crucial role in maintaining immune homeostasis and preventing excessive immune responses. As important suppressors of immune reactions, Tregs help maintain immune tolerance, thereby preventing autoimmune diseases. However, in the tum...

The Therapeutic Role of Interferon-γ in Experimental Autoimmune Encephalomyelitis is Mediated Through a Tolerogenic Subset of Splenic CD11b+ Myeloid Cells

Medicine, Rheumatology and Immunology, Life Sciences, Immunology,
Interferon-γ   Experimental Autoimmune Encephalomyelitis   Splenic CD11b+ Myeloid Cells   Tolerogenic   Multiple Sclerosis   Regulatory T Cells   Immunotherapy  

The Therapeutic Role of IFN-γ in Experimental Autoimmune Encephalomyelitis is Mediated by Tolerogenic Subsets of Splenic CD11b+ Myeloid Cells Research Background Multiple sclerosis (MS) is a chronic autoimmune disease characterized by demyelination and axonal damage in the central nervous system (CNS). Although the etiology of MS is unclear, both g...