Reversal of Beige Fat Decline by Estrogen Through NAMPT-Regulated Endoplasmic Reticulum Stress Response Abstract: Brown adipocytes are valued for their potential therapeutic effects against metabolic diseases. However, the metabolic advantages provided by these cells deteriorate with age. Our research shows that treating mice with estrogen (E2), a ...

The Antitumor Effect of Dual Inhibition of NAMPT and PAK4 in a 3D Spheroid Model of Platinum-Resistant Ovarian Cancer Platinum-resistant ovarian cancer is a malignant gynecological tumor that is difficult to treat and has a short patient survival period. In recent years, researchers have sought new treatment strategies, targeting cancer stem cells ...