Transcriptome Concordance Between Borderline Tumors and Endometrioid Carcinoma: An Integrative Genomic Analysis

Medicine, Obstetrics and Gynecology, Oncology,
borderline ovarian tumor   genomic analysis   ovarian cancer   RNA sequencing   transcriptome   molecular characteristics   tumor microenvironment  

Transcriptomic Concordance Between Borderline Ovarian Tumors and Endometrioid Carcinoma: A Research Study Background Introduction Borderline ovarian tumors (BOTs) are ovarian neoplasms that lie between benign and malignant tumors, typically occurring in young women. Although BOTs are clinically non-invasive, they can occasionally progress to malign...

Patient-Derived Acellular Ascites Fluid Affects Drug Responses in Ovarian Cancer Cell Lines Through the Activation of Key Signalling Pathways

Medicine, Obstetrics and Gynecology, Oncology, Life Sciences, Immunology,
ovarian cancer   acellular ascites fluid   drug sensitivity   signalling pathways   chemoresistance  

Impact of Patient-Derived Acellular Ascites on Drug Responses in Ovarian Cancer Cell Lines Through Activation of Key Signaling Pathways Background Ovarian cancer is one of the deadliest gynecological malignancies, with a 5-year survival rate of only 30% for patients with advanced epithelial ovarian cancer (EOC). Although surgery and chemotherapy (e...

Metabolic Imaging Distinguishes Ovarian Cancer Subtypes and Detects Their Early and Variable Responses to Treatment

Medicine, Obstetrics and Gynecology, Medical Imaging, Oncology,
ovarian cancer   metabolic imaging   high OXPHOS subtype   low OXPHOS subtype   13C magnetic resonance spectroscopy   treatment response  

Metabolic Imaging Distinguishes Ovarian Cancer Subtypes and Detects Their Early and Variable Responses to Treatment Academic Background Ovarian cancer is one of the leading causes of cancer-related deaths in women, with high-grade serous ovarian cancer (HGSOC) being the most common lethal subtype. In recent years, metabolic subtypes have been ident...

SPTLC2 Drives an EGFR-FAK-HBEGF Signaling Axis to Promote Ovarian Cancer Progression

Medicine, Obstetrics and Gynecology, Oncology,
ovarian cancer   EGFR signaling pathway   SPTLC2   tumor progression   metastasis   therapeutic target   cell proliferation  

SPTLC2 Drives an EGFR-FAK-HBEGF Signaling Axis to Promote Ovarian Cancer Progression Academic Background Ovarian cancer (OC) is one of the most lethal cancers in the female reproductive system, with complex pathogenesis and limited treatment options. The epidermal growth factor receptor (EGFR) signaling pathway is widely dysregulated in various can...

Patterns of Genomic Instability in Ovarian Cancer Patients

Medicine, Obstetrics and Gynecology, Oncology, Life Sciences, Biochemistry, Genetics,
ovarian cancer   genomic instability   PARP inhibitors   homologous recombination deficiency   clinical trials   BRCA mutations   precision medicine  

Background and Research Question Ovarian cancer, as a fatal gynecological malignancy, has become the focus of recent studies, particularly on expanding the feasibility of targeted therapies. The introduction of poly(ADP-ribose) polymerase (PARP) inhibitors has marked a groundbreaking treatment option for ovarian cancer, especially for patients with...

Dual-Inhibition of NAMPT and PAK4 Induces Anti-Tumor Effects in 3D-Spheroids Model of Platinum-Resistant Ovarian Cancer

Medicine, Obstetrics and Gynecology, Basic Medical Sciences, Oncology, Life Sciences, Cell Biology, Biochemistry,
ovarian cancer   NAMPT   PAK4   anti-tumor   spheroids   drug resistance  

The Antitumor Effect of Dual Inhibition of NAMPT and PAK4 in a 3D Spheroid Model of Platinum-Resistant Ovarian Cancer Platinum-resistant ovarian cancer is a malignant gynecological tumor that is difficult to treat and has a short patient survival period. In recent years, researchers have sought new treatment strategies, targeting cancer stem cells ...