Disruption of TGF-β signaling pathway is required to mediate effective killing of hepatocellular carcinoma by human iPSC-derived NK cells

Medicine, Hepatobiliary System, Oncology, Life Sciences, Cell Biology, Biochemistry, Bioengineering, Immunology, Genetics,
TGF-β   signaling pathway   NK cells   hepatocellular carcinoma   iPSC   anti-tumor   immunotherapy  

Background Introduction Hepatocellular carcinoma (HCC) is the most common type of primary liver cancer, with a five-year survival rate of less than 20%, and treatment options are extremely limited. Traditional targeted drug therapies, such as Sorafenib and other kinase inhibitors, have been used to treat HCC, but their efficacy is limited and diffi...

Dual-Inhibition of NAMPT and PAK4 Induces Anti-Tumor Effects in 3D-Spheroids Model of Platinum-Resistant Ovarian Cancer

Medicine, Obstetrics and Gynecology, Basic Medical Sciences, Oncology, Life Sciences, Cell Biology, Biochemistry,
ovarian cancer   NAMPT   PAK4   anti-tumor   spheroids   drug resistance  

The Antitumor Effect of Dual Inhibition of NAMPT and PAK4 in a 3D Spheroid Model of Platinum-Resistant Ovarian Cancer Platinum-resistant ovarian cancer is a malignant gynecological tumor that is difficult to treat and has a short patient survival period. In recent years, researchers have sought new treatment strategies, targeting cancer stem cells ...