The Architecture of the Human Default Mode Network Explored through Cytoarchitecture, Wiring and Signal Flow

Exploration of the Architecture of the Human Default Mode Network: A Study Based on Cytoarchitecture, Wiring, and Signal Flow Academic Background The Default Mode Network (DMN) is a set of brain regions that are highly active during resting states, primarily distributed across the frontal, temporal, and parietal lobes. The DMN plays a crucial role ...

Association of Objective Subtle Cognitive Difficulties with Amyloid-β and Tau Deposition in Alzheimer's Disease

Research Progress on Early Alzheimer’s Stages: Focusing on Differences Between Objective Subtle Cognitive Difficulties and Subjective Cognitive Decline Alzheimer’s disease (AD) is a critical topic in modern neuroscience and geriatric medicine research. Its pathological process begins years before the onset of clinical symptoms. Increasing evidence ...

Alterations in Volume and Resting-State Functional Connectivity Detected at Brain MRI in Individuals with Opioid Use Disorder

Multimodal Neuroimaging Study of Structural and Functional Brain Alterations in Individuals with Opioid Use Disorder Academic Background Opioid Use Disorder (OUD) is a complex chronic condition that has multifaceted negative impacts on an individual’s life and is closely associated with an increased risk of mortality. In 2021, over 80,000 deaths in...

Clinicopathologic and Neuroimaging Correlations of Nonverbal Oral Apraxia in Patients with Neurodegenerative Disease

Nonverbal Oral Apraxia in Patients with Neurodegenerative Diseases: Clinical-Pathological and Neuroimaging Correlations Research Background Nonverbal Oral Apraxia (NVOA) is a condition characterized by the inability to plan, sequence, and execute voluntary oral-facial movements without muscle weakness. NVOA was first identified in stroke patients, ...

Graded Multidimensional Clinical and Radiologic Variation in Patients with Alzheimer Disease and Posterior Cortical Atrophy

Research Report on Progressive Multidimensional Clinical and Radiological Variations in Patients with Alzheimer’s Disease and Posterior Cortical Atrophy Background Introduction Alzheimer’s Disease (AD) has multiple phenotypes, including the typical amnestic and non-amnestic (atypical) phenotypes. Posterior Cortical Atrophy (PCA) is a prominent atyp...

Evoked Component Analysis (ECA): Decomposing the Functional Ultrasound Signal with GLM-Regularization

Evoked Component Analysis (ECA): Decomposing Functional Ultrasound Signals Based on GLM Regularization Background The analysis of functional neuroimaging data aims to uncover spatial and temporal patterns of brain activity. Existing data analysis methods mainly fall into two categories: fully data-driven analysis methods and methods that rely on pr...