Circulating Extracellular Vesicles as Promising Biomarkers for Precision Diagnostics: A Perspective on Lung Cancer

Exosomes as Biomarkers for Precision Diagnosis of Lung Cancer Academic Background Lung cancer is one of the leading causes of cancer-related deaths worldwide, with early diagnosis and precision treatment of non-small cell lung cancer (NSCLC) and small cell lung cancer (SCLC) remaining significant challenges. Although traditional tissue biopsy is co...

Patterns of Genomic Instability in Ovarian Cancer Patients

Background and Research Question Ovarian cancer, as a fatal gynecological malignancy, has become the focus of recent studies, particularly on expanding the feasibility of targeted therapies. The introduction of poly(ADP-ribose) polymerase (PARP) inhibitors has marked a groundbreaking treatment option for ovarian cancer, especially for patients with...

Follicular Lymphoma Comprises Germinal Center–Like and Memory-Like Molecular Subtypes with Prognostic Significance

Progress in Molecular Classification of Follicular Lymphoma: A Dual Typing Predictive Model Based on RNA Sequencing and Immunohistochemistry Follicular Lymphoma (FL) is a B-cell malignancy characterized by a slow clinical progression, with a median overall survival extending up to 20 years. However, the heterogeneous nature of FL leads to significa...

Integration of Multi-Omics Data Reveals the Role of Efferocytosis in Lung Adenocarcinoma Prognosis and Immunotherapy

Research Report on Efferocytosis Features and Their Prognostic and Immunotherapy Associations in Lung Adenocarcinoma Background and Research Motivation Lung cancer is a leading cause of cancer-related mortality worldwide, with lung adenocarcinoma (LUAD) being the most common histological subtype. Due to the insidious nature of the disease and lack ...

Tumor Size Is Not Everything: Advancing Radiomics as a Precision Medicine Biomarker in Oncology Drug Development and Clinical Care

In contemporary clinical oncology practice and drug development, the methods for evaluating tumor response are on the cusp of a revolution. Since the World Health Organization (WHO) proposed tumor response classification criteria for assessing the effectiveness of anti-cancer drugs in 1981, this field has undergone several improvements. Notably, th...