Daratumumab in Pediatric Relapsed/Refractory Acute Lymphoblastic Leukemia or Lymphoblastic Lymphoma: The DELPHINUS Study

Medicine, Pediatrics, Hematology, Oncology, Life Sciences, Immunology,
Daratumumab   Acute Lymphoblastic Leukemia   Lymphoblastic Lymphoma   Pediatric   Relapsed/Refractory   DELPHINUS Study   Chemotherapy  

Daratumumab in Pediatric Relapsed/Refractory Acute Lymphoblastic Leukemia or Lymphoblastic Lymphoma: The DELPHINUS Study Academic Background Acute lymphoblastic leukemia (ALL) and lymphoblastic lymphoma (LL) are among the most common malignancies in children. Although the cure rate for newly diagnosed ALL and LL patients is relatively high, 10% to ...

Astrocytic Stress Response Induced by Exposure to Astrocyte-Binding Antibodies in Pediatric Acute Transverse Myelitis Cases

Medicine, Pediatrics, Rheumatology and Immunology, Neurology, Hematology, Life Sciences, Immunology,
Pediatric   Acute Transverse Myelitis   Astrocytes   Antibodies   Neuroinflammation  

B-cell Response in Pediatric Acute Transverse Myelitis Acute transverse myelitis (ATM) is an autoimmune-mediated inflammatory disease of the spinal cord with an incidence of 1.7-2 cases per million children per year. ATM typically presents with limb weakness, sensory loss, and bladder/bowel dysfunction, with symptoms rapidly developing over hours t...

Resistance, Rebound, and Recurrence Regrowth Patterns in Pediatric Low-Grade Glioma Treated by MAPK Inhibition: A Modified Delphi Approach to Build International Consensus

Medicine, Pediatrics, Neurology, Neurosurgery, Oncology,
Pediatric   Low-Grade Glioma   MAPK Inhibition   Resistance   Recurrence   Rebound   Delphi Method  

International Consensus on Resistance, Rebound, and Recurrence in Pediatric Low-Grade Glioma with MAPK Inhibition Therapy: Established Using a Modified Delphi Method Academic Background Pediatric low-grade glioma (PLGG) is the most common type of tumor in the central nervous system of children. Although these tumors have a relatively high overall s...