Phosphorylation of Piezo1 at a Single Residue, Serine-1612, Regulates Its Mechanosensitivity and In Vivo Mechanotransduction Function

Medicine, Basic Medical Sciences, Neurology, Life Sciences, Cell Biology, Biochemistry, Genetics, Biophysics,
Piezo1   Serine-1612   Phosphorylation   Mechanotransduction   Endothelial Cells   Blood Pressure Regulation  

This article is a biomedical research paper authored by scholars such as Zhang Tingxin, Bi Cheng, and Li Yiran, published on November 6, 2024, in the journal “Neuron.” The research was led by a team from the Tsinghua University-Peking University Center for Life Sciences, exploring the regulatory mechanism of phosphorylation modification of the mech...

Drug Treatment Attenuates Retinal Ganglion Cell Death by Inhibiting Collapsin Response Mediator Protein 2 Phosphorylation in Mouse Models of Normal Tension Glaucoma

Medicine, Basic Medical Sciences, Neurology, Ophthalmology, Life Sciences, Cell Biology, Biochemistry,
CRMP2   Normal Tension Glaucoma   Retinal Ganglion Cell   Phosphorylation  

Scientific Research Report: Drug Treatment Alleviates Retinal Ganglion Cell Death in Normal Tension Glaucoma Mouse Model by Inhibiting Collapsin Response Mediator Protein 2 Phosphorylation Background Normal Tension Glaucoma (NTG) is a progressive neurodegenerative disease in the glaucoma family. Typically, glaucoma is associated with elevated intra...

Glycyrrhizic Acid Alleviates Semen Strychni-Induced Neurotoxicity Through the Inhibition of HMGB1 Phosphorylation and Inflammatory Responses

Medicine, Basic Medical Sciences, Neurology, Life Sciences, Biochemistry, Bioengineering,
Semen Strychni   Neurotoxicity   Glycyrrhizic Acid   HMGB1   Phosphorylation  

Research Report on the Mechanism of Glycyrrhizic Acid in Alleviating Neurotoxicity Induced by Semen Strychni Background Introduction Semen Strychni, derived from the dried mature seeds of Strychnos Nux-vomica, has been found to possess various pharmacological activities, including anti-tumor, anti-inflammatory, immunosuppressive, and neuroexcitator...