Tumour Microenvironment-Mediated Drug Resistance in Neuroblastoma

Medicine, Pediatrics, Oncology, Life Sciences, Cell Biology, Biochemistry, Immunology,
Neuroblastoma   Drug Resistance   Tumour Microenvironment   TGF-β1   Nuclear Factor-κB   Therapy  

Background Research Background: Both intrinsic and extrinsic factors in the tumor microenvironment (TME) can lead to treatment resistance. This paper reveals that the Transforming Growth Factor (TGF)-β1 produced within the TME increases drug resistance in neuroblastoma (NB) cells. Drug resistance is the main cause of cancer treatment failure, usual...

An antibody that inhibits TGF-β1 release from latent extracellular matrix complexes attenuates the progression of renal fibrosis

An antibody that inhibits TGF-β1 release from latent extracellular matrix complexes attenuates the progression of renal fibrosis

Medicine, Rheumatology and Immunology, Hepatobiliary System, Nephrology, Oncology, Life Sciences, Cell Biology, Biochemistry, Immunology,
antibody   TGF-β1   renal fibrosis   latent extracellular matrix   selective inhibition  

Study of TGF-β1 in Fibrosis Progression: An Exploration of an Antibody Targeting Binding Proteins Research Background Fibrosis is a leading cause of poor prognosis in numerous diseases, such as chronic kidney disease, non-alcoholic steatohepatitis, and idiopathic pulmonary fibrosis. Despite the substantial medical need, directly targeting fibrosis ...