Depleting Profibrotic Macrophages Using Bioactivated In Vivo Assembly Peptides Ameliorates Kidney Fibrosis

Medicine, Rheumatology and Immunology, Basic Medical Sciences, Nephrology, Life Sciences, Cell Biology, Biochemistry, Immunology,
renal fibrosis   immune microenvironment   profibrotic macrophage   bioactivated in vivo assembly   cell death  

Preface Chronic Kidney Disease (CKD) is a condition characterized by long-term damage to kidney structure, leading to gradual loss of kidney function. Currently, about 10% of adults worldwide are affected by CKD, causing approximately 1.2 million deaths annually. Renal fibrosis is one of the pathological manifestations of CKD, characterized by the ...

An antibody that inhibits TGF-β1 release from latent extracellular matrix complexes attenuates the progression of renal fibrosis

An antibody that inhibits TGF-β1 release from latent extracellular matrix complexes attenuates the progression of renal fibrosis

Medicine, Rheumatology and Immunology, Hepatobiliary System, Nephrology, Oncology, Life Sciences, Cell Biology, Biochemistry, Immunology,
antibody   TGF-β1   renal fibrosis   latent extracellular matrix   selective inhibition  

Study of TGF-β1 in Fibrosis Progression: An Exploration of an Antibody Targeting Binding Proteins Research Background Fibrosis is a leading cause of poor prognosis in numerous diseases, such as chronic kidney disease, non-alcoholic steatohepatitis, and idiopathic pulmonary fibrosis. Despite the substantial medical need, directly targeting fibrosis ...