Age-Dependent Macropinocytosis Drives Resistance to KRAS-G12D–Targeted Therapy in Advanced Pancreatic Cancer

Medicine, Oncology, Life Sciences, Cell Biology, Biochemistry, Immunology,
Pancreatic Cancer   KRAS-G12D   Macropinocytosis   Drug Resistance   Targeted Therapy  

Academic Background and Problem Pancreatic Ductal Adenocarcinoma (PDAC) is an aggressive cancer with an extremely low five-year survival rate, primarily due to late diagnosis and limited treatment options. Approximately 95% of PDAC patients harbor KRAS mutations, with the KRAS-G12D mutation being the most common. Although KRAS mutations have long b...

Tissue Factor Promotes TREX1 Protein Stability to Evade cGAS-STING Innate Immune Response in Pancreatic Ductal Adenocarcinoma

Medicine, Pharmacy, Oncology, Life Sciences, Immunology,
Pancreatic Ductal Adenocarcinoma   Tissue Factor   TREX1 Protein   cGAS-STING Pathway   Immune Evasion   Tumor Microenvironment   Targeted Therapy  

Tissue Factor Promotes TREX1 Protein Stability to Evade cGAS-STING Innate Immune Response in Pancreatic Ductal Adenocarcinoma Academic Background Pancreatic ductal adenocarcinoma (PDAC) remains one of the most challenging malignancies worldwide, with increasing incidence and mortality rates, particularly in advanced stages. Despite significant prog...

Recurrent CLTC::SYK Fusions and CSF1R Mutations in Juvenile Xanthogranuloma of Soft Tissue

Medicine, Pediatrics, Hematology, Oncology, Life Sciences, Immunology, Genetics,
Juvenile Xanthogranuloma   Soft Tissue Tumors   CLTC::SYK Fusion   CSF1R Mutation   Targeted Therapy   Molecular Pathology   Histologic Features  

Research on Juvenile Xanthogranuloma Reveals Novel Genetic Mutations Juvenile xanthogranuloma (JXG), a rare histiocytic neoplasm, typically manifests in the skin but occasionally presents extracutaneously in locations such as soft tissue or the central nervous system (CNS). The genetic drivers underlying these extracutaneous variants remain poorly ...