Single-Cell Analysis of Anti-BCMA CAR T Cell Therapy in Patients with Central Nervous System Autoimmunity

Medicine, Rheumatology and Immunology, Neurology, Life Sciences, Cell Biology, Immunology,
BCMA   CAR T cells   central nervous system   autoimmune diseases   single-cell analysis   neuroinflammation  

Central Nervous System (CNS) autoimmune diseases, such as Neuromyelitis Optica Spectrum Disorders (NMOSD), are inflammatory demyelinating conditions characterized by relapses of optic neuritis and myelitis. Despite significant progress in the treatment of NMOSD, a subset of patients responds poorly to current therapies, with recurrent and difficult...

Targeting T cell plasticity in kidney and gut inflammation by pooled single-cell CRISPR screening

Targeting T cell plasticity in kidney and gut inflammation by pooled single-cell CRISPR screening

Medicine, Rheumatology and Immunology, Nephrology, Gastroenterology, Life Sciences, Immunology,
T cells   plasticity   kidney inflammation   gut inflammation   single-cell CRISPR   autoimmune diseases  

Targeting T Cell Plasticity to Treat Inflammation in the Kidney and Gut: A Study Using Pooled Single-cell CRISPR Screening Background of the Study This paper, co-authored by Leon U.B. Enk and others, was published in the June 14, 2024, issue of “Science Immunology” under the title “Targeting T cell plasticity in kidney and gut inflammation by poole...