Nature of Epigenetic Aging from a Single-Cell Perspective

Medicine, Geriatrics, Life Sciences, Cell Biology, Biochemistry, Genetics,
epigenetic clocks   DNA methylation   single-cell analysis   aging   multiomics data   stochastic changes   gene expression  

Research on the Essence of Epigenetic Aging from a Single-Cell Perspective Research Background As biological research progresses, scientists have discovered that changes in DNA methylation (DNAm) constitute one of the most reliable predictors of age—known as the epigenetic clock. However, the mechanisms underlying what these clocks precisely measur...

Single-Cell Analysis of Anti-BCMA CAR T Cell Therapy in Patients with Central Nervous System Autoimmunity

Medicine, Rheumatology and Immunology, Neurology, Life Sciences, Cell Biology, Immunology,
BCMA   CAR T cells   central nervous system   autoimmune diseases   single-cell analysis   neuroinflammation  

Central Nervous System (CNS) autoimmune diseases, such as Neuromyelitis Optica Spectrum Disorders (NMOSD), are inflammatory demyelinating conditions characterized by relapses of optic neuritis and myelitis. Despite significant progress in the treatment of NMOSD, a subset of patients responds poorly to current therapies, with recurrent and difficult...

Single-cell analysis of anti-BCMA CAR T cell therapy in patients with central nervous system autoimmunity

Single-cell analysis of anti-BCMA CAR T cell therapy in patients with central nervous system autoimmunity

Medicine, Rheumatology and Immunology, Basic Medical Sciences, Life Sciences, Immunology,
single-cell analysis   CAR T cell therapy   central nervous system   autoimmunity   BCMA  

Single-Cell Analysis of Anti-BCMA CAR-T Cell Therapy in Patients with Central Nervous System Autoimmune Diseases Introduction Chimeric Antigen Receptor (CAR) T-cell therapy has shown potential long-term control in treating central nervous system (CNS) autoimmune diseases. This paper investigates the effects of anti-BCMA (B-cell maturation antigen) ...