Gut-Induced Alpha-Synuclein and Tau Propagation Initiate Parkinson’s and Alzheimer’s Disease Co-Pathology and Behavior Impairments

Medicine, Neurology, Gastroenterology, Medical Imaging, Life Sciences, Cell Biology,
alpha-synuclein   tau protein   Parkinson's disease   Alzheimer's disease   behavioral impairments   gut-brain axis   neurodegeneration  

Gastrointestinal-Induced Spread of α-Synuclein and Tau Proteins Triggers Comorbid Pathology and Behavioral Impairments in Parkinson’s and Alzheimer’s Diseases Background Parkinson’s Disease (PD) and Alzheimer’s Disease (AD) are two common neurodegenerative disorders, caused by the aggregation of α-synuclein (a-syn) and Tau protein in the brain, res...

TDRD3-null Mice Show Post-Transcriptional and Behavioral Impairments Associated with Neurogenesis and Synaptic Plasticity

Medicine, Neurology, Life Sciences, Cell Biology, Genetics,
TDRD3   TOP3B   neurogenesis   synaptic plasticity   behavioral impairments   neurological disorders  

TDRD3 Deficient Mice Exhibit Deficits in Neurogenesis and Synaptic Plasticity at Both Post-transcriptional and Behavioral Levels Research Background Topoisomerase 3b (top3b) is a dual-activity topoisomerase capable of resolving DNA and RNA topological problems. An increasing body of evidence indicates that top3b functions as a conserved complex wit...