Gut-Induced Alpha-Synuclein and Tau Propagation Initiate Parkinson’s and Alzheimer’s Disease Co-Pathology and Behavior Impairments

Medicine, Neurology, Gastroenterology, Medical Imaging, Life Sciences, Cell Biology,
alpha-synuclein   tau protein   Parkinson's disease   Alzheimer's disease   behavioral impairments   gut-brain axis   neurodegeneration  

Gastrointestinal-Induced Spread of α-Synuclein and Tau Proteins Triggers Comorbid Pathology and Behavioral Impairments in Parkinson’s and Alzheimer’s Diseases Background Parkinson’s Disease (PD) and Alzheimer’s Disease (AD) are two common neurodegenerative disorders, caused by the aggregation of α-synuclein (a-syn) and Tau protein in the brain, res...

Brain vasculature accumulates tau and is spatially related to tau tangle pathology in Alzheimer's disease

Medicine, Medical Laboratory Science, Geriatrics, Neurology, Oncology, Life Sciences, Cell Biology, Biochemistry,
Alzheimer's disease   tau protein   neurofibrillary tangles   blood vessels   cerebral vasculature   cerebral amyloid angiopathy  

Study of Tau Protein Accumulation in Brain Vasculature in Alzheimer’s Disease Background Introduction Alzheimer’s disease is characterized by neurodegeneration, with primary pathological features including amyloid plaques and neurofibrillary tangles (NFTs). These tangles are composed of tau protein, and these pathological changes are closely relate...

p-tau217 correlates with neurodegeneration in Alzheimer’s disease, and targeting p-tau217 with immunotherapy ameliorates murine tauopathy

Medicine, Basic Medical Sciences, Neurology, Life Sciences, Biochemistry,
p-tau217   Alzheimer’s disease   neurodegeneration   immunotherapy   tau protein   brain atrophy   cognitive impairment  

Correlation between p-tau217 and Alzheimer’s Disease Neurodegeneration and the Ameliorative Effects of Targeting p-tau217 Immunotherapy in Mouse Tauopathy Introduction Neuron loss is a core issue in Alzheimer’s Disease (AD). However, to date, no therapy can halt the neurodegenerative changes associated with AD. Tau is a microtubule-associated prote...