Co-registration of MALDI-MSI and histology demonstrates gangliosides co-localize with amyloid beta plaques in Alzheimer’s disease

Co-registration of MALDI-MSI and histology demonstrates gangliosides co-localize with amyloid beta plaques in Alzheimer’s disease

Medicine, Medical Laboratory Science, Neurology, Medical Imaging, Life Sciences, Biochemistry, Immunology,
Alzheimer's disease   gangliosides   lipids   MALDI-MSI   digital pathology  

Co-localization of Gangliosides with Amyloid Beta Plaques in Alzheimer’s Disease Detected by MALDI-MSI and Histology Alzheimer’s Disease (AD) is a progressive neurodegenerative disease characterized by cognitive impairment and behavioral changes. Historically, AD research has focused on misfolded proteins, but with advancements in mass spectrometry...

Distinct Patterns of Plaque and Microglia Glycosylation in Alzheimer’s Disease

Distinct Patterns of Plaque and Microglia Glycosylation in Alzheimer’s Disease

Medicine, Neurology, Life Sciences, Biochemistry,
Alzheimer’s disease   digital pathology   glycosylation   microglia   senile plaque   sialylation  

Unique Patterns of Glycosylation in Plaques and Microglia in Alzheimer’s Disease Research Background Alzheimer’s disease (AD) is the most common form of dementia and a devastating neurodegenerative disorder. AD is characterized by two pathological features: extracellular β-amyloid (Aβ) plaques and intracellular phosphorylated Tau neurofibrillary ta...