Suppression of Myd88 Disturbs Gut Microbiota and Activates the NLR Pathway and Hence Fails to Ameliorate DSS-Induced Colitis

Medicine, Gastroenterology, Life Sciences, Immunology,
Myd88   gut microbiota   NLR pathway   colitis   inflammatory bowel disease  

Inflammatory Bowel Disease (IBD) is a chronic, relapsing inflammatory disorder of the gastrointestinal tract, primarily including Ulcerative Colitis (UC) and Crohn’s Disease (CD). In recent years, the incidence of IBD has been on the rise globally, placing a significant burden on healthcare systems. Although it is widely accepted that IBD is associ...

Hydrogen Gas and the Gut Microbiota as Potential Biomarkers for the Development of Experimental Colitis in Mice

Medicine, Gastroenterology, Life Sciences, Immunology, Microbiology,
gut microbiota   hydrogen gas   experimental colitis   inflammatory bowel disease   biomarker  

Inflammatory Bowel Disease (IBD) is a chronic inflammatory condition that primarily includes Ulcerative Colitis (UC) and Crohn’s Disease (CD). The incidence of IBD has been increasing globally, imposing significant health and economic burdens on patients and society. Currently, the diagnosis of IBD relies mainly on endoscopy, but this method is exp...

Neutrophil-derived PAD4 induces citrullination of CKMT1 exacerbates mucosal inflammation in inflammatory bowel disease

Medicine, Infectious Diseases, Rheumatology and Immunology, Gastroenterology, Life Sciences, Immunology,
neutrophil   citrullination   CKMT1   intestinal epithelial cells   inflammatory bowel disease   intestinal inflammation   apoptosis  

In recent years, increasing evidence from research on Inflammatory Bowel Disease (IBD) has shown that neutrophils play a crucial role in the occurrence and development of intestinal inflammation. IBD includes Crohn’s Disease (CD) and Ulcerative Colitis (UC), and while its pathogenesis is not yet fully understood, abnormal immune responses are clear...