Inflammatory Bowel Disease (IBD) is a chronic inflammatory condition that primarily includes Ulcerative Colitis (UC) and Crohn’s Disease (CD). The incidence of IBD has been increasing globally, imposing significant health and economic burdens on patients and society. Currently, the diagnosis of IBD relies mainly on endoscopy, but this method is exp...

Anxiety Disorder Identification and Biomarker Detection Based on Subspace-Enhanced Hypergraph Neural Network Academic Background Anxiety Disorders (ADs) are prevalent mental health issues globally, affecting approximately 7.3% of the population. Patients with anxiety disorders typically exhibit excessive fear, worry, and related behavioral abnormal...

Biomarkers Associated with the Progression of Infantile Hemangioma: An Exploratory Study Academic Background Infantile Hemangioma (IH) is one of the most common benign tumors in infancy. Although most IH is not apparent at birth, it gradually manifests within the first month of life and undergoes a proliferative phase over approximately one year, f...

Clinical Significance of Stratifying Prostate Cancer Patients Through Specific Circulating Genes Academic Background Prostate Cancer (PCA) is the most common cancer among men in North America and a leading cause of cancer-related mortality. Although many patients are diagnosed with organ-confined disease, 25-35% experience recurrence after curative...

Plasma S100β as a Predictor for Pathology and Cognitive Decline in Alzheimer’s Disease Academic Background Alzheimer’s Disease (AD) is the most common form of dementia, characterized by the deposition of β-amyloid (Aβ) plaques and the aggregation of hyperphosphorylated microtubule-associated protein tau (tau). These pathological changes lead to gra...

Prevalence and Clinical Significance of Claudin-3 Expression in Cancer: A Tissue Microarray Study on 14,966 Tumor Samples Academic Background Claudin-3 (Cldn3) is a member of the Claudin family, involved in the formation of tight junctions (TJs), which regulate intercellular permeability. TJs play a crucial role in maintaining the barrier function ...

Cascading Pattern in Genetic Risk Research for Alzheimer’s Disease Background and Research Motivation Alzheimer’s disease (AD) is a slowly progressing neurodegenerative disorder characterized by the accumulation of two pathological features: amyloid plaques and phosphorylated tau neurofibrillary tangles. These pathological features typically exist ...

A Study Exploring a New Mutation in Early-Onset Alzheimer’s Disease Alzheimer’s Disease (AD) is a common neurodegenerative disorder, accounting for 60-70% of all dementia cases. In recent years, with global population aging and environmental changes, the incidence of AD has been increasing annually. It is predicted that by 2050, the number of patie...

Brain-Derived Exosomal Circular RNAs in Plasma as Diagnostic Biomarkers for Acute Ischemic Stroke Acute ischemic stroke (AIS), commonly known as stroke, is a serious condition characterized by interrupted blood flow to the brain, resulting in tissue damage and neurological deficits. Early diagnosis is crucial for effective intervention and manageme...

Prediction of Invasiveness and Treatment Resistance Behavior of Pituitary Neuroendocrine Tumors Based on Genome-Wide Loss of Heterozygosity Background: Pituitary neuroendocrine tumors (PitNETs) are mostly benign, but a small portion exhibit invasive and treatment-resistant behaviors, continuing to grow or metastasize even after surgery, conventiona...