Complete Inhibition of Liver Acetyl-CoA Carboxylase Activity Exacerbates Liver Tumorigenesis in Mice Treated with Diethylnitrosamine

Medicine, Hepatobiliary System, Oncology, Life Sciences, Biochemistry,
liver cancer   de novo lipogenesis   acetyl-CoA carboxylase   tumorigenesis   diethylnitrosamine   metabolic pathway   mouse model  

Inhibition of Liver Acetyl-CoA Carboxylase (ACC) Activity Exacerbates Liver Tumorigenesis in Mice Academic Background Liver cancer is the sixth most common cancer globally and the third leading cause of cancer-related mortality. Hepatocellular carcinoma (HCC) is the most common type of primary liver cancer. In recent years, the burden of liver canc...

Pharmacogenomic Profiling of Intra-Tumor Heterogeneity Using a Large Organoid Biobank of Liver Cancer

Pharmacogenomic Profiling of Intra-Tumor Heterogeneity Using a Large Organoid Biobank of Liver Cancer

Medicine, Hepatobiliary System, Basic Medical Sciences, Oncology, Life Sciences, Cell Biology,
liver cancer   intra-tumor heterogeneity   pharmacogenomics   organoid biobank   biomarkers   drug resistance   combination therapy  

Analysis of Intratumor Heterogeneity in Liver Cancer Using Pharmacogenomics: A Study Based on a Large-Scale Organoid Biobank Academic Background Primary liver cancer (PLC) is the third leading cause of cancer-related deaths worldwide, mainly comprising hepatocellular carcinoma (HCC), intrahepatic cholangiocarcinoma (ICC), and a mixed form called co...