The Mevalonate Pathway Contributes to Breast Primary Tumorigenesis and Lung Metastasis

Medicine, Oncology,
mevalonate pathway   breast cancer   lung metastasis   Rho GTPases   cholesterol   gene expression   tumor recurrence  

Regulation of the Mevalonate Pathway in Breast Cancer and Its Role in Tumorigenesis and Lung Metastasis Background Introduction Breast cancer is one of the most common cancers among women worldwide, and its occurrence and metastasis mechanisms are complex, involving abnormal regulation of multiple signaling pathways and metabolic processes. In rece...

Tryptophan 2,3-Dioxygenase-Positive Matrix Fibroblasts Fuel Breast Cancer Lung Metastasis via Kynurenine-Mediated Ferroptosis Resistance of Metastatic Cells and T Cell Dysfunction

Medicine, Oncology, Life Sciences, Cell Biology, Immunology,
matrix fibroblasts   lung metastasis   tryptophan 2,3-dioxygenase   T cell dysfunction   ferroptosis  

Mechanism of Stromal Fibroblasts in Breast Cancer Lung Metastasis Background Introduction Breast cancer is one of the most common cancers among women worldwide, and metastasis is the leading cause of death in breast cancer patients. The lung is one of the most common sites of breast cancer metastasis, yet the mechanisms underlying this process rema...