A Bimodal Taxonomy of Adult Human Brain Sulcal Morphology Related to Timing of Fetal Sulcation and Trans-Sulcal Gene Expression Gradients

A Bimodal Taxonomy of Adult Human Brain Sulcal Morphology Related to Timing of Fetal Sulcation and Trans-Sulcal Gene Expression Gradients

Medicine, Neurology, Medical Imaging, Life Sciences, Cell Biology, Biochemistry, Genetics,
brain sulci   sulcal morphology   fetal development   gene expression   morphology  

Research Background and Objectives This study focuses on the complex morphological features of the adult cerebral cortex sulci, specifically the classification of linear and complex morphologies of brain sulci and their developmental mechanisms. The sulci are groove structures on the surface of the cerebral cortex, corresponding to different geneti...

Gene Expression Alterations in the Spinal Cord of SIV-Infected Macaques on Antiretroviral Therapy

Medicine, Infectious Diseases, Neurology, Life Sciences, Cell Biology, Immunology,
SIV   HIV   spinal cord   antiretroviral therapy   gene expression   neuropathy  

NARP Laboratory Research Reveals the Impact of SIV Infection on Spinal Cord Gene Expression Background Despite the implementation of antiretroviral therapy (ART), HIV-associated peripheral neuropathy (HIV-DSP) remains one of the most common neurological manifestations of HIV infection. Clinical symptoms of HIV-DSP include weakness, numbness, burnin...

Spatiotemporal Transcriptomic Changes of Human Ovarian Aging and the Regulatory Role of FOXP1

Medicine, Obstetrics and Gynecology, Geriatrics, Life Sciences, Biochemistry, Genetics,
ovarian aging   single-cell RNA sequencing   spatial transcriptomics   FOXP1   gene expression   DNA damage   cell types  

Research Report on Spatiotemporal Transcriptomic Changes in Human Ovarian Aging and the Regulatory Role of FOXP1 Academic Background With the continuous increase in global average life expectancy, health issues faced by women during menopause are receiving increasing attention. Ovarian aging is one of the significant issues, closely related to vari...

Nature of Epigenetic Aging from a Single-Cell Perspective

Medicine, Geriatrics, Life Sciences, Cell Biology, Biochemistry, Genetics,
epigenetic clocks   DNA methylation   single-cell analysis   aging   multiomics data   stochastic changes   gene expression  

Research on the Essence of Epigenetic Aging from a Single-Cell Perspective Research Background As biological research progresses, scientists have discovered that changes in DNA methylation (DNAm) constitute one of the most reliable predictors of age—known as the epigenetic clock. However, the mechanisms underlying what these clocks precisely measur...

Transcriptomic Sex Differences in Postmortem Brain Samples from Patients with Psychiatric Disorders

Transcriptomic Sex Differences in Postmortem Brain Samples from Patients with Psychiatric Disorders

Medicine, Basic Medical Sciences, Psychiatry,
sex differences   psychiatric disorders   transcriptomics   postmortem brain samples   gene expression   co-expression networks  

Analysis of Gender Differences in Transcriptomes of Postmortem Brain Tissues from Psychiatric Patients Background Gender differences in psychiatric patients are a well-documented phenomenon. Disorders such as Schizophrenia (SCZ), Bipolar Disorder (BD), and Autism Spectrum Disorder (ASD) all exhibit significant gender differences. However, the speci...

Cortical gene expression architecture links healthy neurodevelopment to the imaging, transcriptomics and genetics of autism and schizophrenia

Medicine, Psychiatry, Neurology, Life Sciences, Cell Biology, Biochemistry, Immunology, Genetics,
neurodevelopment   gene expression   autism   schizophrenia   neuroimaging  

Linking Healthy Neurodevelopment with Imaging, Transcriptomic, and Genetic Associations in Autism Spectrum Disorder and Schizophrenia: A Study of Cortical Gene Expression Patterns Background: How does the complex anatomy and functional organization of the human brain develop from the expression of more than 20,000 genes? And how does this process g...