Enhancing Gene Delivery to Breast Cancer with Highly Efficient siRNA Loading and pH-Responsive Small Extracellular Vesicles Academic Background In recent years, small extracellular vesicles (sEVs) have become a hot topic in the field of drug delivery due to their natural origin and inherent homing properties. sEVs are lipid nanoparticles secreted b...

Regulation of the Mevalonate Pathway in Breast Cancer and Its Role in Tumorigenesis and Lung Metastasis Background Introduction Breast cancer is one of the most common cancers among women worldwide, and its occurrence and metastasis mechanisms are complex, involving abnormal regulation of multiple signaling pathways and metabolic processes. In rece...

Dynamic Changes in Estrogen Receptor Alpha (ERα) Promoter Methylation and Drug Resistance in Breast Cancer Cells Background Breast cancer is one of the most common cancers among women worldwide, with approximately 75% of breast cancer patients expressing estrogen receptor alpha (ERα, gene symbol ESR1). ERα is not only an important prognostic marker...

Targeting ERK1/2 and p38 MAPK Pathways Attenuates Golgin-97 Depletion-Induced Breast Cancer Progression Research Background Breast cancer is the most common type of cancer among women worldwide, with triple-negative breast cancer (TNBC) having a particularly high metastasis rate and poor prognosis. TNBC lacks expression of estrogen receptor, proges...

HER2 Expression Dynamics in Breast Cancer Brain Metastases and Its Impact on Survival Background Breast cancer is one of the most common cancers among women worldwide, and brain metastases (BrMs) pose a significant challenge for patients. In recent years, with the prolonged survival of breast cancer patients, the incidence of brain metastases has g...

Association of CHEK2 Low-Risk Variants with Cancer Phenotypes Academic Background The CHEK2 gene (OMIM 604373) is one of the susceptibility genes for breast cancer. Monoallelic pathogenic variants (PVs) in CHEK2 are associated with an increased risk of breast, colorectal, kidney, and thyroid cancers. However, there is limited research on the phenot...

Association Between Cardiovascular Disease and Breast Cancer Stage at Diagnosis Academic Background Cardiovascular disease (CVD) and cancer are the two leading causes of mortality in the United States. Although they share many common risk factors, recent studies suggest that CVD may directly promote the occurrence and progression of cancer. Specifi...

Report on the Study of Cardiac Dysfunction Among Breast Cancer Survivors Academic Background Breast cancer is the most common cancer diagnosed in women. Advances in early detection and novel therapeutics have yielded 5-year survival rates exceeding 90%. However, with over four million breast cancer survivors in the United States today, the quality ...

The Impact of a Statewide Regionalization Policy on Travel Distance for Initial Breast Cancer Surgery Academic Background Breast cancer is one of the most common cancers among women globally, and the quality of treatment and patient survival rates are closely related to the allocation of medical resources. Studies have shown that high-volume medica...

Academic Background Breast cancer is one of the most common cancers among women worldwide, particularly triple-negative breast cancer (TNBC) and hormone receptor-positive/human epidermal growth factor receptor 2-negative (HR+/HER2-) breast cancer, which are known for their aggressive nature and poor prognosis. In recent years, immune checkpoint inh...