Macrophages are Activated Toward Phagocytic Lymphoma Cell Clearance by Pentose Phosphate Pathway Inhibition

Medicine, Oncology, Life Sciences, Cell Biology, Biochemistry, Immunology,
macrophages   lymphoma   pentose phosphate pathway   immune regulation   metabolic modulation  

Academic Background The tumor microenvironment (TME) is a critical area in cancer research, where tumor cells interact with surrounding non-tumor cells to influence disease progression and therapeutic responses. Tumor-associated macrophages (TAMs) play a pivotal role in tumor growth, angiogenesis, and immune suppression. Recently, the role of metab...

ARID1A orchestrates SWI/SNF-mediated sequential binding of transcription factors with ARID1A loss driving pre-memory B cell fate and lymphomagenesis

Medicine, Hematology, Oncology, Life Sciences, Cell Biology, Biochemistry, Genetics,
ARID1A   SWI/SNF   transcription factors   memory B cells   lymphoma   chromatin remodeling   cancer  

ARID1A Loss and B Cell Fate and Lymphoma Occurrence Background Introduction This paper investigates the critical role of ARID1A (AT-Rich Interactive Domain 1A) in B cell fate determination and lymphoma occurrence. ARID1A is an important subunit of the BRG1/Brahma-associated factors (BAF) complex, with mutations commonly found in various human malig...