Genome-Wide Single-Cell and Single-Molecule Footprinting of Transcription Factors with Deaminase

Life Sciences, Cell Biology, Biochemistry, Genetics,
transcription factors   deaminase   single-molecule sequencing   single-cell genomics   TF binding cooperativity  

Genome-Wide Single-Cell and Single-Molecule Footprinting of Transcription Factors with Deaminase Academic Background In humans and other mammals, although the genome of each somatic cell is essentially the same, the functions of different cell types vary significantly. This diversity is primarily determined by the binding of transcription factors (...

ARID1A orchestrates SWI/SNF-mediated sequential binding of transcription factors with ARID1A loss driving pre-memory B cell fate and lymphomagenesis

Medicine, Hematology, Oncology, Life Sciences, Cell Biology, Biochemistry, Genetics,
ARID1A   SWI/SNF   transcription factors   memory B cells   lymphoma   chromatin remodeling   cancer  

ARID1A Loss and B Cell Fate and Lymphoma Occurrence Background Introduction This paper investigates the critical role of ARID1A (AT-Rich Interactive Domain 1A) in B cell fate determination and lymphoma occurrence. ARID1A is an important subunit of the BRG1/Brahma-associated factors (BAF) complex, with mutations commonly found in various human malig...