Multiscale Footprints Reveal the Organization of Cis-Regulatory Elements

Multiscale Footprints Reveal the Role of Cis-Regulatory Elements in Cell Differentiation and Aging Background Introduction The regulation of gene expression is a key mechanism in cell fate determination and disease development, and cis-regulatory elements (CREs) play a crucial role in this process. CREs dynamically regulate gene expression by bindi...

Genome-Wide Single-Cell and Single-Molecule Footprinting of Transcription Factors with Deaminase

Genome-Wide Single-Cell and Single-Molecule Footprinting of Transcription Factors with Deaminase Academic Background In humans and other mammals, although the genome of each somatic cell is essentially the same, the functions of different cell types vary significantly. This diversity is primarily determined by the binding of transcription factors (...

ARID1A orchestrates SWI/SNF-mediated sequential binding of transcription factors with ARID1A loss driving pre-memory B cell fate and lymphomagenesis

ARID1A Loss and B Cell Fate and Lymphoma Occurrence Background Introduction This paper investigates the critical role of ARID1A (AT-Rich Interactive Domain 1A) in B cell fate determination and lymphoma occurrence. ARID1A is an important subunit of the BRG1/Brahma-associated factors (BAF) complex, with mutations commonly found in various human malig...