PTDP-43 Levels Correlate with Cell Type–Specific Molecular Alterations in the Prefrontal Cortex of C9orf72 ALS/FTD Patients

Medicine, Neurology, Life Sciences, Cell Biology, Immunology, Genetics,
neurodegenerative disorders   PTDP-43   C9orf72   prefrontal cortex   single-nucleus multiome analysis  

Correlation between PTDP-43 Levels and Cell-Specific Molecular Alterations in the Prefrontal Cortex of C9orf72 ALS/FTD Patients Background Introduction Amyotrophic Lateral Sclerosis (ALS) and Frontotemporal Dementia (FTD) are two types of progressive neurodegenerative diseases. Their common feature is the loss of specific neuronal populations in th...

Propagation of Pathologic α-Synuclein from Kidney to Brain May Contribute to Parkinson’s Disease

Medicine, Urology, Nephrology, Neurology, Life Sciences,
Parkinson’s disease   α-synuclein   renal function   pathologic propagation   neurodegenerative disorders  

Pathological Link Between Kidney Disease and Parkinson’s Disease Academic Background Parkinson’s disease (PD) is a common neurodegenerative disorder characterized by the abnormal aggregation of α-synuclein (α-syn) in the brain, forming Lewy bodies (LBs) and Lewy neurites (LNs). In recent years, increasing evidence suggests that the pathological agg...