Background Colorectal cancer is the third most common cancer type globally, with the greatest disease burden in East Asia. In China, 47% of newly diagnosed colorectal cancers are rectal cancers, of which 70% are radiologically staged as locally advanced (stage II/III) at diagnosis. For decades, neoadjuvant chemoradiotherapy (CRT) combined with tota...

Phenotypic Plasticity of TREM1+ Mono-Macrophages Mediated by Radiotherapy Combined with Immunochemotherapy in Locally Advanced Rectal Cancer: A Comprehensive Multi-Omics Study Background Introduction Rectal cancer is the second leading cause of cancer-related deaths worldwide, accounting for one-third of all colorectal cancer cases. While surgical ...