Radiation-Induced Cellular Plasticity Primes Glioblastoma for Forskolin-Mediated Differentiation

Medicine, Neurology, Neurosurgery, Oncology, Life Sciences, Cell Biology, Biochemistry, Bioengineering,
glioblastoma   cellular plasticity   forskolin   differentiation therapy   radiotherapy  

Radiation-Induced Cellular Plasticity Primes Glioblastoma for Forskolin-Mediated Differentiation Academic Background Glioblastoma (GBM) is one of the deadliest brain cancers in adults, with a median survival period of only 15 to 18 months for patients. Although surgery combined with chemoradiotherapy can delay disease progression, these treatments ...

Improving Glioblastoma Treatment with Imaging, Radiotherapy, Drug Delivery, and Therapeutic Systems

Medicine, Neurology, Neurosurgery, Medical Imaging, Oncology,
glioblastoma   imaging techniques   radiotherapy   drug delivery systems   therapeutic devices  

Improving Glioblastoma Treatment with Imaging, Radiotherapy, Drug Delivery, and Therapeutic Systems Academic Background Glioblastoma (GBM) is the most common and aggressive type of brain cancer, with an extremely poor prognosis and a five-year survival rate of less than 10%. Despite decades of extensive research in drug therapy, radiation therapy, ...

Role of Radiotherapy-Induced TREM1+ Mono-Macrophages in Rectal Cancer

Medicine, Rheumatology and Immunology, Oncology, Life Sciences, Cell Biology, Biochemistry, Immunology,
radiotherapy   TREM1+   rectal cancer   monocytes   immunotherapy   antitumor immunity   biomarkers  

Phenotypic Plasticity of TREM1+ Mono-Macrophages Mediated by Radiotherapy Combined with Immunochemotherapy in Locally Advanced Rectal Cancer: A Comprehensive Multi-Omics Study Background Introduction Rectal cancer is the second leading cause of cancer-related deaths worldwide, accounting for one-third of all colorectal cancer cases. While surgical ...

Protein-functionalized and intrinsically radiolabeled 188Re oxide nanoparticles: advancing cancer therapy through concurrent radio-photothermal effects

Chemistry, Nanoscience, Medicinal Chemistry, Materials Chemistry, Medicine, Medical Imaging, Oncology,
protein-functionalized   188Re   radiotherapy   photothermal therapy   tumor treatment   nanoparticles   dual-modality imaging  

Protein-Functionalized and Intrinsically Radiolabeled [188Re]ReOx Nanoparticles: Breakthrough Application in Multimodal Synergistic Cancer Therapy Cancer remains one of the leading causes of death globally, despite significant progress in medical science over the past few decades. However, early detection and treatment methods still face significan...

The Role of Radioresistant-Related Telomere Genes in the Prognosis and Immune Infiltration of Lung Adenocarcinoma

Medicine, Respiratory System, Oncology, Life Sciences, Cell Biology, Biochemistry, Immunology, Genetics,
lung adenocarcinoma   radiotherapy   telomere genes   immune infiltration   prognostic model  

The Impact of Radioresistant-Related Telomere Genes on Prognosis and Immune Infiltration in Lung Adenocarcinoma Lung adenocarcinoma (LUAD), a common subtype of non-small cell lung cancer (NSCLC), has a high incidence and mortality rate. Despite significant progress in early detection and treatment, the overall survival (OS) rate of LUAD patients re...

Predicting the risk of neurocognitive decline after brain irradiation in adult patients with a primary brain tumor

Medicine, Neurology, Neurosurgery, Oncology,
brain tumor   radiotherapy   neurocognitive decline   prediction model  

Background Introduction: Radiotherapy is a major treatment modality for brain tumor patients, but it can cause cognitive decline as a side effect, which is one of the most concerning complications. Currently, there is a lack of tools in clinical practice to assess the risk of cognitive decline in patients. The purpose of this study is to establish ...