Neoadjuvant Cabozantinib for Locally Advanced Nonmetastatic Clear Cell Renal Cell Carcinoma: A Phase 2 Trial

Medicine, Urology, Nephrology, Oncology, Life Sciences, Immunology,
renal cell carcinoma   cabozantinib   neoadjuvant therapy   locally advanced   clinical trial  

Academic Background Renal Cell Carcinoma (RCC) is one of the cancers with a rapidly rising incidence globally, particularly among young patients and minorities. In the United States, an estimated 81,610 new cases of RCC will be diagnosed in 2024, with approximately 30% progressing to metastatic RCC. For locally advanced RCC, the initial treatment i...

Reoperation for Ipsilateral Local Recurrence Following Prior Nephron-Sparing Surgery: Innovative Surgical Insights from a High-Volume Urological Center with Cross-Sectional Study

Medicine, Urology, Oncology,
local recurrence   nephron-sparing surgery   reoperation   surgical strategies   renal cell carcinoma   robotic-assisted surgery   laparoscopic surgery  

Innovative Surgical Strategies for Reoperation of Local Recurrence in Renal Cell Carcinoma Academic Background Renal cell carcinoma (RCC) is one of the most common malignant tumors in adults, accounting for 5% of malignancies in males and 3% in females. Although surgery remains the standard treatment for localized RCC, nephron-sparing surgery (NSS)...

Prevalence and Clinical Significance of Claudin-3 Expression in Cancer: A Tissue Microarray Study on 14,966 Tumor Samples

Medicine, Obstetrics and Gynecology, Urology, Nephrology, Oncology,
Claudin-3   tissue microarray   cancer   renal cell carcinoma   biomarker  

Prevalence and Clinical Significance of Claudin-3 Expression in Cancer: A Tissue Microarray Study on 14,966 Tumor Samples Academic Background Claudin-3 (Cldn3) is a member of the Claudin family, involved in the formation of tight junctions (TJs), which regulate intercellular permeability. TJs play a crucial role in maintaining the barrier function ...