A Temporal Cortex Cell Atlas Highlights Gene Expression Dynamics During Human Brain Maturation

Medicine, Neurology, Life Sciences, Cell Biology, Genetics,
temporal cortex   single-nucleus RNA sequencing   brain maturation   gene expression   cell subtypes   cognition   synaptic plasticity  

Gene Expression Dynamics During Human Brain Maturation: A Novel Temporal Cortex Cell Atlas Academic Background The development and maturation of the human brain are critical areas in neuroscience, though many mysteries remain unresolved. Guided by changes in gene expression, the human brain undergoes a prolonged and complex postnatal maturation pro...

Integrating Single-Nucleus RNA Sequencing and Spatial Transcriptomics to Elucidate a Specialized Subpopulation of Astrocytes, Microglia, and Vascular Cells in a Mouse Model of Lipopolysaccharide-Induced Sepsis-Associated Encephalopathy

Medicine, Infectious Diseases, Neurology, Life Sciences, Cell Biology, Immunology,
sepsis   sepsis-associated encephalopathy   single-nucleus RNA sequencing   spatial transcriptomics   ANXA1   glial cell response   cellular localization  

Study on Mouse Sepsis-Associated Encephalopathy Based on Single Cell and Spatial Transcriptomics Background Organ dysfunction leading to death in sepsis is related to an imbalance in the host’s response to infection, and it has a high global mortality rate. Recent studies have shown that sepsis can cause brain dysfunction, known as sepsis-associate...