Integrating Single-Nucleus RNA Sequencing and Spatial Transcriptomics to Elucidate a Specialized Subpopulation of Astrocytes, Microglia, and Vascular Cells in a Mouse Model of Lipopolysaccharide-Induced Sepsis-Associated Encephalopathy

Medicine, Infectious Diseases, Neurology, Life Sciences, Cell Biology, Immunology,
sepsis   sepsis-associated encephalopathy   single-nucleus RNA sequencing   spatial transcriptomics   ANXA1   glial cell response   cellular localization  

Study on Mouse Sepsis-Associated Encephalopathy Based on Single Cell and Spatial Transcriptomics Background Organ dysfunction leading to death in sepsis is related to an imbalance in the host’s response to infection, and it has a high global mortality rate. Recent studies have shown that sepsis can cause brain dysfunction, known as sepsis-associate...

Spatiotemporal Transcriptomic Changes of Human Ovarian Aging and the Regulatory Role of FOXP1

Medicine, Obstetrics and Gynecology, Geriatrics, Life Sciences, Biochemistry, Genetics,
ovarian aging   single-cell RNA sequencing   spatial transcriptomics   FOXP1   gene expression   DNA damage   cell types  

Research Report on Spatiotemporal Transcriptomic Changes in Human Ovarian Aging and the Regulatory Role of FOXP1 Academic Background With the continuous increase in global average life expectancy, health issues faced by women during menopause are receiving increasing attention. Ovarian aging is one of the significant issues, closely related to vari...

Spatial Enrichment and Genomic Analyses Reveal the Link of NOMO1 with Amyotrophic Lateral Sclerosis

Spatial Enrichment and Genomic Analyses Reveal the Link of NOMO1 with Amyotrophic Lateral Sclerosis

Medicine, Rheumatology and Immunology, Basic Medical Sciences, Neurology, Life Sciences, Immunology, Genetics,
spatial transcriptomics   genomics   spatial enrichment   amyotrophic lateral sclerosis  

Spatial Enrichment and Genomic Analysis Reveal Association between NOMO1 and Amyotrophic Lateral Sclerosis Introduction Amyotrophic lateral sclerosis (ALS) is a severe neurodegenerative disease in which motor neurons in the brain and spinal cord gradually degrade. Although the genetic susceptibility of sporadic ALS patients remains uncertain, TDP-4...