Mapping Tumor Habitats in Isocitrate Dehydrogenase-Wild Type Glioblastoma: Integrating MRI, Pathologic, and RNA Data

Medicine, Neurology, Medical Imaging, Oncology,
glioblastoma   tumor habitats   MRI   pathology   RNA sequencing   spatial heterogeneity   IDH-wild type  

Pathological Validation of MRI Tumor Habitats in Glioblastoma Background Introduction Glioblastoma (GBM) is a highly malignant brain tumor characterized by significant heterogeneity and invasiveness. Due to its complex tumor microenvironment (TME), traditional imaging methods struggle to accurately distinguish different tumor regions, such as the t...

A Prognostic Molecular Signature of Hepatic Steatosis is Spatially Heterogeneous and Dynamic in Human Liver

Medicine, Hepatobiliary System, Endocrinology, Gastroenterology,
hepatic steatosis   molecular signature   spatial heterogeneity   dynamic   liver   metabolic disease   biomarkers  

Academic Background Metabolic-associated Steatotic Liver Disease (MASLD) is a major health issue affecting over 30% of the global population and is closely related to various chronic diseases such as cancer, cardiovascular disease, and renal dysfunction. The pathological spectrum of MASLD ranges from simple steatosis to steatohepatitis and progress...