Phase II Trial of Pathology-Based Tripartite Treatment Stratification for Patients with CNS Germ Cell Tumors: A Long-Term Follow-Up Study

Medicine, Neurology, Neurosurgery, Oncology,
CNS germ cell tumors   long-term follow-up   tripartite treatment   pathology   survival rates   relapse   complications  

Long-Term Follow-Up Study of Central Nervous System Germ Cell Tumors: Pathology-Based Tripartite Treatment Stratification Academic Background Central nervous system germ cell tumors (CNS GCTs) are rare tumors primarily occurring in adolescents, especially males aged 12 to 16. These tumors are believed to originate from primordial germ cells (PGCs),...

Infiltration of M2a Macrophages is Predominant in Genital Verruciform Xanthoma

Medicine, Life Sciences, Immunology,
M2a macrophages   verruciform xanthoma   genital   immunohistochemistry   pathology  

Predominant Infiltration of M2a Macrophages in Genital Verruciform Xanthoma Academic Background Verruciform xanthoma (VX) is a rare benign verrucous tumor first reported by Sachs in 1903 and formally named by Shafer in 1971. This lesion primarily occurs in the genital area and oral mucosa of elderly individuals. Histopathologically, it is character...

Mapping Tumor Habitats in Isocitrate Dehydrogenase-Wild Type Glioblastoma: Integrating MRI, Pathologic, and RNA Data

Medicine, Neurology, Medical Imaging, Oncology,
glioblastoma   tumor habitats   MRI   pathology   RNA sequencing   spatial heterogeneity   IDH-wild type  

Pathological Validation of MRI Tumor Habitats in Glioblastoma Background Introduction Glioblastoma (GBM) is a highly malignant brain tumor characterized by significant heterogeneity and invasiveness. Due to its complex tumor microenvironment (TME), traditional imaging methods struggle to accurately distinguish different tumor regions, such as the t...

Distinct Ultrastructural Phenotypes of Glial and Neuronal Alpha-Synuclein Inclusions in Multiple System Atrophy

Medicine, Rheumatology and Immunology, Basic Medical Sciences, Neurology,
multiple system atrophy   glial cells   neurons   alpha-synuclein   ultrastructure   pathology   human brain  

Different Ultrastructural Phenotypes of α-Synuclein Inclusions in Glia and Neurons in Brain Regions of Multiple System Atrophy (MSA) Introduction Multiple System Atrophy (MSA) is a severe neurodegenerative disease characterized by abnormal accumulation of α-Synuclein (α-Syn) in specific brain regions, forming pathological inclusions that primarily ...