Mapping Tumor Habitats in Isocitrate Dehydrogenase-Wild Type Glioblastoma: Integrating MRI, Pathologic, and RNA Data

Medicine, Neurology, Medical Imaging, Oncology,
glioblastoma   tumor habitats   MRI   pathology   RNA sequencing   spatial heterogeneity   IDH-wild type  

Pathological Validation of MRI Tumor Habitats in Glioblastoma Background Introduction Glioblastoma (GBM) is a highly malignant brain tumor characterized by significant heterogeneity and invasiveness. Due to its complex tumor microenvironment (TME), traditional imaging methods struggle to accurately distinguish different tumor regions, such as the t...

Distinct Ultrastructural Phenotypes of Glial and Neuronal Alpha-Synuclein Inclusions in Multiple System Atrophy

Medicine, Rheumatology and Immunology, Basic Medical Sciences, Neurology,
multiple system atrophy   glial cells   neurons   alpha-synuclein   ultrastructure   pathology   human brain  

Different Ultrastructural Phenotypes of α-Synuclein Inclusions in Glia and Neurons in Brain Regions of Multiple System Atrophy (MSA) Introduction Multiple System Atrophy (MSA) is a severe neurodegenerative disease characterized by abnormal accumulation of α-Synuclein (α-Syn) in specific brain regions, forming pathological inclusions that primarily ...