Population-wide DNA Methylation Polymorphisms at Single-Nucleotide Resolution in 207 Cotton Accessions Reveal Epigenomic Contributions to Complex Traits

Life Sciences, Cell Biology, Biochemistry, Bioengineering, Genetics, Botany,
cotton   DNA methylation   gene expression   epigenetics   fiber quality  

Cotton Population-Level DNA Methylation Polymorphism Study Reveals Epigenomic Contributions to Complex Traits Background and Research Motivation In recent decades, genome and genetic diversity have been extensively studied through genome-wide association studies (GWAS), providing a theoretical foundation for understanding crop trait variations. How...

Functional and Epigenetic Changes in Monocytes from Adults Immunized with an AS01-Adjuvanted Vaccine

Life Sciences, Cell Biology, Biochemistry, Immunology, Microbiology,
vaccine   monocytes   AS01 adjuvant   epigenetics   immune response   activation  

Long-term Functional and Epigenetic Changes in Adult Monocytes Induced by AS01-adjuvanted Vaccine Background: Vaccine adjuvants are widely used to enhance the immune response of vaccines. In particular, the AS01 adjuvant, a key component in several approved vaccines, has demonstrated high immunogenicity and efficacy. AS01 exerts its adjuvant effect...

Uncovering Sex-Specific Epigenetic Regulatory Mechanism Involving H3K9me2 in Neural Inflammation, Damage, and Recovery in the Internal Carotid Artery Occlusion Mouse Model

Medicine, Neurology, Life Sciences, Cell Biology, Biochemistry, Immunology,
cerebral ischemia   sex-difference   inflammation   KDM4B/JMJD2B   striatum   epigenetics  

Research Reveals Gender-Specific Epigenetic Regulatory Mechanisms in Neuroinflammation, Injury, and Recovery Background Ischemic stroke is one of the leading causes of death and disability worldwide. Due to limited understanding of its linked disease mechanisms, current treatments for alleviating acute ischemic brain injury are very limited. Recent...

CRISPR dependency screens in primary hematopoietic stem cells identify KDM3B as a genotype-specific vulnerability in IDH2- and TET2-mutant cells

Medicine, Basic Medical Sciences, Oncology, Life Sciences, Biochemistry,
hematopoietic stem cells   KDM3B   epigenetics   clonal hematopoiesis   CRISPR screens   acute myeloid leukemia  

CRISPR-Dependent Screening in Primary Hematopoietic Stem Cells Identifies KDM3B as Specific Susceptibility for IDH2 and TET2 Mutant Genotypes Background and Significance Clonal Hematopoiesis (CH) refers to the abnormal growth of genetically distinct subclones of cells initiated by specific mutations in Hematopoietic Stem Cells (HSCs). This phenomen...

Associations of Epigenetic Age Estimators with Cognitive Function Trajectories in the Women's Health Initiative Memory Study

Medicine, Geriatrics, Neurology, Life Sciences, Biochemistry, Genetics,
epigenetics   age estimation   cognitive function   women's health   memory  

Association Between Epigenetic Age Acceleration Estimates and Cognitive Trajectories in the Women’s Health Initiative Memory Study Background Maintaining cognitive function is crucial for independent living among older adults. With the growth of the aging population, cognitive decline has become a significant public health challenge. Many studies h...

Genome-Wide Repeat Landscapes in Cancer and Cell-Free DNA

Genome-Wide Repeat Landscapes in Cancer and Cell-Free DNA

Medicine, Basic Medical Sciences, Oncology, Life Sciences, Genetics,
cancer   genome-wide repeats   cell-free DNA   liquid biopsy   early detection   structural variant   epigenetics  

A Panoramic View of Whole Genome Repetitive Sequences in Cancer and Circulating Free DNA Research Background and Significance Throughout the development of cancer and other diseases, genetic changes in repetitive sequences within the genome are a significant characteristic. However, standard sequencing methods struggle to effectively characterize t...