Cellular Communication Network Factor 2 Regulates Smooth Muscle Cell Transdifferentiation and Lipid Accumulation in Atherosclerosis

Background Introduction Atherosclerosis is a complex vascular disease characterized by the progressive accumulation of lipid plaques within the arterial walls, ultimately leading to cardiovascular events such as myocardial infarction, stroke, and peripheral vascular disease. Although the current standard treatment regimen includes statins and antip...

Metabolism of Primary High-Grade Serous Ovarian Carcinoma (HGSOC) Cells under Limited Glutamine or Glucose Availability

Metabolism of High-Grade Serous Ovarian Carcinoma (HGSOC) Cells Academic Background High-Grade Serous Ovarian Carcinoma (HGSOC) is the most common and aggressive subtype of epithelial ovarian cancer. Most patients are diagnosed at stage III or IV, with a 5-year survival rate ranging from 20% to 40%. Treatment for HGSOC typically involves surgical r...

Revealing Endoplasmic Reticulum Stress-Related CAF Subpopulations Associated with Chordoma Progression

Revealing Endoplasmic Reticulum Stress-Related CAF Subpopulations Associated with Chordoma Progression

Introduction Chordoma is a rare and locally aggressive mesenchymal tumor, believed to originate from the remnant tissues of the primitive notochord. The incidence of chordoma is approximately 0.8 per million, with a predilection for the sacral and skull base regions. Currently, the optimal treatment strategy is maximal safe surgical resection follo...